口腔颌面-头颈良恶性肿瘤，包括舌癌、牙龈癌、颊癌、口咽癌、颌骨肿瘤以及涎腺肿瘤等免疫治疗以及手术切除和同期功能性修复重建(股前外侧瓣、腓骨肌皮瓣、腓骨肌筋膜瓣、前臂瓣、胸大肌瓣等各种游离和带蒂组织瓣)；颌骨放射性骨坏死修复重建；颌面颈部内镜微创手术；血管瘤和脉管畸形综合治疗；颅颌面外伤救治。

范松 医学博士 口腔科副主任 博士研究生导师 羊城好医生 美国癌症研究协会(AACR)会员 哈佛大学麻省总院肿瘤外科博士后 广东省杰出青年医学人才 广东省杰出青年科学基金获得者 本科毕业于中山大学光华口腔医学院即留校就职于中山大学孙逸仙纪念医院口腔颌面外科（国家临床重点专科）从事口腔颌面良恶性肿瘤的临床治疗以及基础研究。近年来主要从事颌面软硬组织数字化精准修复重建、颅颌面部内镜微创手术以及头颈肿瘤的免疫治疗。率先开展颌面-头颈恶性肿瘤的新辅助免疫治疗和辅助免疫治疗，并取得了很好的临床疗效；在颌面肿瘤切除精准修复重建方面创立了制备超薄股前外侧瓣的Honeycomb技术以及舌癌个性化半舌和标准全舌功能性修复重建的FIPELS技术，极大的推动力颌面肿瘤术后的功能和美观的恢复；同时还在国际上首次开展经颌下单一小切口内镜辅助下早期口腔癌择区性颈淋巴清扫术以及内镜辅助经颅耳沟径路的腮腺微创手术，不仅保证肿瘤的切除效果且从根本上同时实现了微创和美观并重。基础研究方面主要研究内容包括头颈部实体瘤的线粒体功能和免疫调控机制以及免疫治疗。相关研究成果已以第一作者或通信作者在国外重要肿瘤学杂志《Clin Cancer Res》、《Cancer Res》、《Oncogene》、《Theranostics》、《Oral Oncol》、《Ann Surg Oncol》、《Plast Reconstr Surg》、《Surg Endosc》、《Head Neck》等发表SCI收录论文40余篇，其中包括封面文章3篇以及ESI高被引论文。2016-2018年于哈佛大学麻省总院肿瘤外科进行博士后研究工作（头颈癌免疫治疗）。近年主持国家自然科学基金等各类项目8项，获批经费逾800万元。获中山大学青年教师重点培育项目以及“逸仙优秀青年医学人才”培养计划；入选中山大学孙逸仙纪念医院“高层次人才特别支持计划”三个三青年拔尖人才项目。 社会任职 广东省美容整形协会委员，2014年-至今 广东省医学会颌面-头颈外科学分会秘书，委员，2019-2023 广东省抗癌协会头颈肿瘤专业委员会青年委员会副主任委员，2020-至今 中国卫生信息与健康医疗大数据学会口腔医学专业委员会委员，2019-2023 广东省口腔颌面头颈数字化精准修复重建工程技术研究中心副主任 中国医疗保健国际交流促进会肿瘤整形外科与功能性外科分会青年委员，2016-至今 广东省医学会显微外科学分会第七届委员会口腔颌面头颈修复学组成员 获奖荣誉 广东省杰出青年医学人才 获中山大学青年教师重点培育项目以及“逸仙优秀青年医学人才”培养计划 入选中山大学孙逸仙纪念医院“高层次人才特别支持计划”三个三青年拔尖人才项目 科研成果 以第一作者或通信作者在国外重要肿瘤学杂志《Clin Cancer Res》、《Cancer Res》、《Cancer Lett》、《Theranostics》、《Oral Oncol》、《Ann Surg Oncol》、《Plast Reconstr Surg》、《Surg Endosc》、《Head Neck》等发表SCI收录论文30篇，其中包括封面文章3篇以及ESI高被引论文。 近年主持国家自然科学基金等各类项目8项，获批经费逾800万元。 主要论著 1. Peng Y#, Xiao L#, Rong H#, Ou Z, Cai T, Liu N, Li B, Zhang L, Wu F, Lan T, Lin X, Li Q, Ren S, Fan S*, Li J*. Single-cell profiling of tumor-infiltrating TCF1/TCF7+ T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer. Oral Oncol. 2021 May 25; 119:105348. (IF= 4.273) 2. Lei X#, Ou Z#, Yang Z#, Zhong J#, Zhu Y#, Tian J, Wu J, Deng H, Lin X, Peng Y, Li B, He L, Tu Z, Chen W, Li Q, Liu N, Zhang H, Wang Z, Fang Z, Yamada T, Lv X, Tian T, Pan G, Wu F, Xiao L, Zhang L, Cai T, Wang X, Tannous BA, Li J*, Kontos F, Ferrone S*, Fan S*. A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3-Specific CAR T Cells in Solid Tumors. Clin Cancer Res. 2021 Apr 2. (IF=10.107) 3. Zhang F#, Tang X#, Fan S#, Liu X#, Sun J, Ju C, Liang Y, Liu R, Zhou R, Yu B, Zhang C, Zhang Z, Kang T, Huang G*, Lv XB*. Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors. Oncogene. 2021 Jun;40(24):4137-4150. (IF: 7.971) 4. Liu M#, Liu Q#, Fan S#, Su F, Jiang C, Cai G, Wang Y, Liao G, Lei X, Chen W, Bi J, Cheng W, Zhao L, Ruan Y*, Li J*. LncRNA LTSCCAT promotes tongue squamous cell carcinoma metastasis via targeting the miR-103a-2-5p/SMYD3/TWIST1 axis. Cell Death Dis. 2021 Feb 1;12(2):144. (IF=6.304) 5. Zhidong Sun#, Fan Wu#, Huichang Gao, Kai Cui, Mengyue Xian, Jianglong Zhong, Ye Tian, Song Fan*, and Gang Wu*. A Dexamethasone-Eluting Porous Scaffold for Bone Regeneration Fabricated by Selective Laser Sintering. ACS Applied Bio Materials. 2020 3 (12), 8739-8747 6. Zhao L#, Ye Y#, Jiao J#, Liao J, Lin Z, Zhong J, Wu J, Fang Z, Kontos F, Chen W, Huang X, Dias-Ribeiro E, Yang Z*, Li J, Fan S*. Comparison of postoperative cytokine and hormone between endoscopically assisted and open parotid tumor resection. Oral Dis. 2020 Nov 14. (IF=2.613) 7. Julierme Ferreira Rocha, Song Fan, Eduardo Dias-Ribeiro. A new method to calculate the maximum dose of local anesthetics. Arch Health Invest .2020 9(3):210-210. 8. Zhang L#, Li B#, Peng Y#, Wu F, Li Q, Lin Z, Xie S, Xiao L, Lin X, Ou Z, Cai T, Rong H, Fan S*, Li J*. The prognostic value of TMB and the relationship between TMB and immune infiltration in head and neck squamous cell carcinoma: A gene expression-based study. Oral Oncol. 2020 Nov;110:104943. (IF=3.979) 9. Fan S*, Kontos F. Minimally Invasive Surgery: Straight Thinking and Still a Long Way to Go. Clin Surg. 2020; 5: 2733 10. Fan S#*, Tian T#, Lv X#, Lei X#, Yang Z, Liu M, Liang F, Li S, Lin X, Lin Z, Xie S, Li B, Chen W, Pan G, Lin X, Ou Z, Zhang Y, Peng Y, Xiao L, Zhang L, Sun S, Zhang H, Lin S, Li Q, Zeng B, Kontos F, Ruan Y*, Ferrone S, Lin D, Tannous BA and Li J*. lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter. iScience. 2020 Feb 21;23(2):100835. (IF= 4.447) 11. Fu S#, Li JS#, Dias-Ribeiro E*, Palhano-Freire JC, Sun S, Fan S*. Aggressive Surgical Resection of Enormous Cervical Metastasis from Nasopharyngeal Carcinoma. Acta Stomatol Croat. 2019 Jun;53(2):168-173. 12. Fan S#, Tian T#, Chen W#, Lv X#, Lei X, Zhang H, Sun S, Cai L, Pan G, He L, Ou Z, Lin X, Wang X, Perez MF, Tu Z, Ferrone S*, Tannous BA, Li J*. Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription. Cancer Res. 2019 Mar 15;79(6):1069-1084. (IF= 9.13) 13. Tian T#, Lv X #, Pan G #, Lu Y #, Chen W #, Wang He, Lei X, Zhang H, Liu M, Sun S, Ou Z, Lin X, Cai L, He L, Tu Z, Wang X, Tannous BA, Ferrone S, Li J *, Fan S *. Long Noncoding RNA MPRL Promotes Mitochondrial Fission and Cisplatin Chemosensitivity via Disruption of Pre-miRNA Processing. Clin Cancer Res. 2019 Jun 15;25(12):3673-3688. (IF= 10.199) 14. Chen W#, Wang P#, Lu Y#, Jin T#, Lei X, Liu M, Zhuang P, Liao J, Lin Z, Li B, Peng Y, Pan G, Lv X, Zhang H, Ou Z, Xie S, Lin X, Sun S, Ferrone S, Tannous BA, Ruan Y*, Li J*, Fan S*. Decreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation. Theranostics. 2019 Aug 12;9(20):5739-5754. （IF= 8.06） 15. Fan S#*, Zhang H#, Li Q#, Liang F, Bai Z, Chen W, Sun S, Yu P, Li J*. novel anatomy-based five-points eight-line-segments technique for precision subtotal tongue reconstruction: A pilot study. Oral Oncol. 2019 Feb;89:1-7. (IF= 4.636) 16. Fan S#, Li QX#, Zhang HQ#, Liang MJ, Tian T, Wang YY, Lin ZY, Chen WX, Pan GK, Ahn MH, He L, Sun S, Wu BH, Yu P*, Li JS*. "Five-point eight-line" anatomic flap design for precise hemitongue reconstruction. Head Neck. 2019 May;41(5):1359-1366. (IF= 2.471) 17. Zeng B#, Liao J#, Zhang H#, Fu S, Chen W, Pan G, Li Q, Chen W, Ferrone S, Wu B, Sun S, Hu J, Ahn MH, Lin Z, Yu D, Ou Z, Wang X, Mo F, Huang N, Hamilton JA, Li J*, Fan S*. Novel ANO5 mutation c.1067G＞T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia. Head Neck. 2019 Jan;41(1):230-238. (IF= 2.471) 18. Fan S#, Zhang HQ#, Li QX#, Tian T, Chen WX, Pan GK, Ho-Young Ahn M, Sun S, Wu BH, Li JS*. The Use of a Honeycomb Technique Combined with Ultrasonic Aspirators and Indocyanine Green Fluorescence Angiography for a Superthin Anterolateral Thigh Flap: A Pilot Study. Plast Reconstr Surg. 2018 Jun;141(6):902e-910e. (IF= 3.475) 19. Zhang HQ#, Li QX#, Wang YY, Wang ZS#, Lin ZY, Sha LJ, Zhang DM, Liu J, Wang JJ, Li JS*, Fan S*. Combination of biomechanical evaluation and accurate placement of dental implants: a new concept of virtual surgery in maxillary and mandibular functional reconstruction. Br J Oral Maxillofac Surg. 2020 Jan;58(1):62-68. 20. Shen ZS#, Li JS#, Chen WL, Fan S*. The Latest Advancements in Selective Neck Dissection for Early Stage Oral Squamous Cell Carcinoma. Curr Treat Options Oncol. 2017 May;18(5):31. (IF= 3.562) 21. Fan S#, Chen WX#, Lv XB#, Tang QL#, Sun LJ, Liu BD, Zhong JL, Lin ZY, Wang YY, Li QX, Yu X, Zhang HQ, Li YL, Wen B, Zhang Z, Chen WL, Li JS*. miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1. Cancer Lett. 2015 Jul 1;362(2):183-91. (IF=6.491) 22. Fan S#, Liu B#, Sun L#, Lv XB#, Lin Z#, Chen W, Chen W, Tang Q, Wang Y, Su Y, Jin S, Zhang D, Zhong J, Li Y, Wen B, Zhang Z, Yang P, Zhou B, Liang Q, Yu X, Zhu Y, Hu P, Chu J, Huang W, Feng Y, Peng H, Huang Q, Song E*, Li J*. Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1-miR-593-5p-MFF axis. Oncotarget. 2015 Jun 20;6(17):14885-904. 23. Fan S#, Pan GK#, Chen WL, Lin ZY, Liang FY, Li QX, Zhang DM, Wang YY, Zhang HQ, Chen WX, Chen R, Huang XM, Ye JT*, Li JS*. Endoscope-assisted extracapsular dissection of benign parotid tumors through a single cephaloauricular furrow incision versus a conventional approach. Surg Endosc. 2017 Aug;31(8):3203-3209. (IF=3.54) 24. Xie SL#, Fan S#, Zhang SY#, Chen WX, Li QX, Pan GK, Zhang HQ, Wang WW, Weng B, Zhang Z, Li JS*, Lin ZY*. SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt/β-catenin pathway. Int J Cancer. 2018 Mar 15;142(6):1252-1265. 25. Fan S#, Zhang DM#, Chen WL*. Endoscopy-Assisted Resection of Benign Lesions on the Base of the Tongue via the Transoral Approach Using a Harmonic Scalpel. J Oral Maxillofac Surg. 2017 Oct;75(10):2242-2247. 26. Liang F#, Fan S#, Han P, Cai Q, Lin P, Chen R, Yu S, Huang X*. Endoscopic-assisted selective neck dissection via small lateral neck incision for early-stage (T1-2N0M0) head and neck squamous cell carcinoma: 3-year follow-up results. Surg Endosc. 2017 Feb;31(2):894-900. (IF=3.54) 27. Fan S#, Wang YY, Lin ZY, Zhang DM, Yu X, Chen WX, Zhong JL, Li QX, Feng YH, Chen WL, Pan CB, Dias-Ribeiro E, Sonoda CK, Ye JT*, Li JS*. Synchronous reconstruction of bilateral osteoradionecrosis of the mandible using a single fibular osteocutaneous flap in patients with nasopharyngeal carcinoma. Head Neck. 2016 Apr;38 Suppl 1: E607-12. (IF=2.76) 28. Fan S#, Wang YY, Wu DH, Lai DL, Feng YH, Yu X, Lin ZY, Zhang DM, Chen WL, Liang JQ, Li JS*. Intraoral lining with the fibular osteomyofascial flap without a skin paddle during maxillary and mandibular reconstruction. Head Neck. 2016 Apr;38 Suppl 1: E832-6. (IF=2.76) 29. Fan S#, Liang FY#, Chen WL*, Yang ZH, Huang XM, Wang YY, Lin ZY, Zhang DM, Zhou B, Chen WX, Chai Q, Wang HJ, Pan CB, Liang QX, Yu X, Dias-Ribeiro E, Feng YH, Li JS*. Minimally invasive selective neck dissection: a prospective study of endoscopically assisted dissection via a small submandibular approach in cT(1-2_N(0) oral squamous cell carcinoma. Ann Surg Oncol. 2014 Nov;21(12):3876-81. (IF=3.66) 30. Fan S#, Zhong JL#, Chen WX#, Chen WL*, Li QX, Wang YY, Lin ZY, Zhang HQ, Zhang DM, Yu X, Liang FY, Huang XM, Dias-Ribeiro E, Liu Y, Lin XH, Zhou B, Liang QX, Sonoda CK, Li JS*. Postoperative immune response and surgical stress in selective neck dissection: Comparison between endoscopically assisted dissection and open techniques in cT1-2N0 oral squamous cell carcinoma. J Craniomaxillofac Surg. 2017 Aug;45(8):1112-1116. (IF=1.59) 31. Wang YY#, Fan S#, Zhang HQ, Lin ZY, Ye JT, Li JS*. Virtual Surgical Planning in Precise Maxillary Reconstruction With Vascularized Fibular Graft After Tumor Ablation. J Oral Maxillofac Surg. 2016 Jun;74(6):1255-64. (IF=1.63) 32. Fan S#, Lin SG#, Zhang HQ#, Li QX, Chen WX, Wang YY, Zhang DM, Lin ZY, Zhong JL, Chen WL*, Li JS*. A comparative study of the endoscopy-assisted transoral approach versus external approaches for the resection of large benign parapharyngeal space tumors. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Feb;123(2):157-162. (IF=1.26) 33. Tang QL#, Fan S#, Li HG, Chen WL*, Shen XM, Yuan XP, Chang SH, Song Y. Expression of Cyr61 in primary salivary adenoid cystic carcinoma and its relation to Ki-67 and prognosis. Oral Oncol. 2011 May;47(5):365-70. (IF=4.29) 34. Fan S#, Tang QL#, Lin YJ#, Chen WL*, Li JS, Huang ZQ, Yang ZH, Wang YY, Zhang DM, Wang HJ, Dias-Ribeiro E, Cai Q, Wang L. A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. Int J Oral Sci. 2011 Oct;3(4):180-91. (IF=2.59) 35. Fan S#, Chen WL*, Yang ZH, Huang ZQ.Comparison of the efficiencies of permanent maxillary tooth removal performed with single buccal infiltration versus routine buccal and palatal injection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Mar;107(3):359-63. (IF=1.26) 36. Fan S#, Chen WL*, Pan CB, Huang ZQ, Xian MQ, Yang ZH, Dias-Ribeiro E, Liang YC, Jiao JY, Ye YS, Wen TY. Anesthetic efficacy of inferior alveolar nerve block plus buccal infiltration or periodontal ligament injections with articaine in patients with irreversible pulpitis in the mandibular first molar. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov;108(5):e89-93. (IF=1.63) 37. Fan S*, Chen WL, de Lima-Júnior JL, Dias-Ribeiro E. Concerns about anesthetizing palatal tissues. J Oral Maxillofac Surg. 2011 Feb;69(2):574. 38. Ferreira-Junior O*, de Avila LD, Sampieri MB, Dias-Ribeiro E, Chen WL, Fan S*. Impacted lower third molar fused with a supernumerary tooth--diagnosis and treatment planning using cone-beam computed tomography. Int J Oral Sci. 2009 Dec;1(4):224-8. (IF=2.59) 教育经历 本科中山大学光华口腔医学院口腔颌面外科